CBD For Chronic Back Pain
Using CBD for chronic back pain has been shown to have a lot of benefits. It can help relieve pain and also help to heal your body. Using CBD for chronic back pain can help you get through the day and avoid having to take pain medications.
Cannabidiol
Using cannabidiol for chronic back pain can help reduce pain and improve sleep. However, the clinical effects of this drug need to be studied further.
The endocannabinoid system is a set of chemical receptors in the body that regulates the release of neurotransmitters and other chemicals in the body. It is found in the central nervous system and immune cells.
Research on cannabinoids and their effects on pain has increased in recent years. However, there are a limited number of studies that provide high-quality evidence about their effectiveness. Several clinical trials have investigated the use of cannabinoids as adjunct therapy to standard analgesic modalities.
The CANBACK trial tested a placebo and 400 mg oral CBD in 100 emergency department patients with acute, non-traumatic, low back pain. Patients had a moderate to severe pain level at baseline. It was found that the pain improved at the end of the study. The study concluded that cannabidiol is not a better alternative than placebo in the treatment of acute, non-traumatic low back pain.
Terpene Profiles
Depending on the strain, cannabis can have terpene profiles that help to fight inflammation, relieve pain, and boost overall health. It’s important to understand what terpenes are, how they are created, and how they affect you.
Terpenes are hydrocarbons that are formed when the flower of a cannabis plant is dried. They are produced in a gland that produces cannabinoids, which are the primary signaling compounds in the endocannabinoid system (ECS).
Terpenes have been linked to a number of therapeutic effects, including anti-inflammatory, antimicrobial, anti-bacterial, anti-carcinogenic, and anti-spasmic. Pinene, an alpha-dihydroxy terpene, is a potent anti-inflammatory that helps with common pain types, including arthritis and multiple sclerosis. Pinene also has an expectorant effect that may help with respiratory distress. In addition, pinene has anti-cancer effects, a potential benefit in treating pain related to cancer.
Another terpene, limonene, is found in citrus fruits and citrus rinds. Limonene is believed to fight anxiety, inflammation, and stress. It also has an anti-carcinogenic effect, and it helps stimulate the immune system.
Anti-Inflammatory Effects
Several studies have demonstrated the anti-inflammatory effects of CBD. However, more robust research is needed to understand the precise mechanisms involved.
CBD inhibits oxidative stress, inflammation, and pain. It is a positive allosteric modulator for anionic ligand-gated ion channels. It binds to the CB1 and CB2 receptors, primarily located in the central nervous system (CNS) and immune system. In addition, it inhibits the activity of LOX15 and LOX5, two other inflammatory mediators. In a mouse model of chronic neuropathic pain, CBD reduced thermal allodynia and mechanical sensitivity. In a hot plate thermal nociceptive assay, CBD and morphine produced synergistic effects.
CBD inhibits the activity of LOX5 with an IC50 of 73,730 nM. It also inhibits the activity of FAAH with an IC50 of over 25,000 nM. These findings suggest that CBD may be a positive allosteric modulator of the FAAH-induced apoptosis in inflammatory-activated cells.
The analgesic effects of CBD vary depending on the dosage and route of administration. The effects of CBD are mediated through the serotoninergic system and are correlated with the binding affinity of CBD to CB1 and CB2 receptors.
Legality In The United States
Despite some states having legalized the use of CBD for chronic back pain, the legality of CBD for chronic back pain in the United States is not clear. This is because the legal status of cannabis is constantly changing, and laws are not consistent from state to state.
In the United States, CBD is considered a Schedule I drug along with heroin and LSD. CBD is not intoxicating, but it can alter the way certain medicines work.
Some people believe CBD can ease anxiety related to chronic pain. However, research has yet to fully prove this claim. It is also important to note that CBD research in older adults is in its infancy.
In the United States, CBD is not legally prescribed by physicians. Rather, they can issue prescriptions for pain medications. CBD should not be considered a replacement for pain care treatments, but rather an option to be discussed with your doctor.
However, physicians can’t dispense CBD if it’s derived from marijuana, even if it’s legal in your state. This is because marijuana is still illegal at the federal level.
